The most up to date information on the work in translational genomics and bioinformatics for David Craig is at his lab home page.
Precision medicine is founded on the premise of tailoring medical decisions, practices, and treatments to the unique genomic, genetic, epigenetic, proteomic and clinical profiles of patients. The Craig Laboratory is focused on development the experimental frameworks and informatics systems systems to gather, integrate, analyze patient data at multiple scales and time points in decision making that has clinical value and utility. centered in an emerging area of Multiscale Translational Bioinformatics.
Today we are moving from the ability to genome-wide sequence data for a single patient to in the coming year being able to generate in single molecule data (such as from exome sequencing, RNA-seq or methyl-Seq) not just from one cell but hundreds to thousands of cells together with cellular biology and different clinical measurements (such as from imaging and pathology). While the technology and data are forthcoming, considerably research and development is needed to optimally leverage and bridge together data spanning molecules, cells, tissues. Consequentially, the goal of our research is to develop approaches for integrating and modelling data spanning from the individual nucleic acid molecules and cells to system level clinical measurements in order improve our ability to understand disease diagnosis, treatment, progression, and prevention.